Differential effects of C5a on human and mouse mast cells may be mediated by C5aR and C5L2
نویسندگان
چکیده
Rationale The complement anaphylatoxin 5a (C5a) is an inflammatory mediator associated with the pathology of inflammatory diseases such as sepsis. C5a mediates its pro-inflammatory effects via interaction with two C5a receptors, C5aR and C5L2. C5aR initiates G proteincoupled receptor signaling while C5L2 is not coupled to G proteins and its role in C5a-mediated immune processes is not well understood. We hypothesized that mast cells (MC) expressed C5aR and/or C5L2 and that C5a activated MC through these receptors.
منابع مشابه
The seven-transmembrane receptor, C5L2, is a stimulatory receptor on human mast cells
Background Complement anaphylatoxin 5a (C5a) is a powerful inflammatory mediator involved in the pathology of inflammatory diseases such as chronic idiopathic urticaria. C5a binds to two receptors, C5aR, a G protein-coupled receptor, and C5L2, a 7-transmembrane receptor deficient in G protein coupling. The role of C5L2 in human mast cells (huMC) is unknown. We hypothesized that huMC express C5a...
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